HN tordable 3/28/2026

ChatGPT Will Not Find Your Next Cancer Drug

Technical discussion of LLM capabilities in drug discovery: reading thousands of papers, finding non-obvious connections between mechanisms across disease areas.

HN RichAwo 3/28/2026

Whisper AI Local Mac Setup

Guide for running OpenAI's Whisper speech-to-text model locally on macOS for privacy-preserving transcription.

HN kinlan 3/28/2026

The Prompt Is the Program

Application built entirely as a markdown file interpreted by Claude, demonstrating prompt-as-program paradigm with git integration.

HN arrowsmith 3/27/2026

How LLMs Feel Language

Analysis of how LLMs process language through cognitive semantics framework, examining meaning representation beyond tokens.

HN kaycebasques 3/27/2026

Day Zero of Multi-Vector Retrieval

ColBERT-Zero: Multi-vector retrieval model trained from scratch using dense-to-sparse adaptation for enterprise search.

HN simvux 3/27/2026

Quadratic Micropass Type Inference

Research on type inference algorithm that improves error messages by prioritizing correct type assumptions over incorrect ones.

HN susros 3/27/2026

Appaca: Personal Software Platform

Appaca platform generates custom software from natural language descriptions using AI. LLM application for software generation but lacks technical depth.